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Huh7 cells expressing SUN1 H118Y accumulated significantly more lipid than WT SUN1-expressing cells, with or without oleic acid treatment (all P 50% steatosis) fatty livers
Long-term study results are currently limited, but the following must be considered for shaping the clinical algorithm in GLP-1 RA prescribing: proper indication, the characteristics of the prescribed drug, the patient's psychiatric and somatic history, sociodemographic factors, patient expectations, and especially monitoring of response to rapid weight loss (Figure 1)
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10.1038/s41557-024-01532-x Nat Chem
At 25C (typical room temperature), reconstituted MT-2 begins degrading within 24 hours and loses an estimated 3050% of its potency within 72 hours
The mechanism is universal
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